Title: Debulking surgery in the setting of very high-risk prostate cancer scenarios
Authors: Oderda, Marco ×
Joniau, Steven
Spahn, Martin
Gontero, Paolo #
Issue Date: Sep-2012
Publisher: Blackwell Science
Series Title: BJU International vol:110 issue:6 Pt B pages:E192-8
Article number: 10.1111/j.1464-410X.2012.10942.x
Abstract: What's known on the subject? and What does the study add? Nowadays radical prostatectomy (RP) is considered an effective treatment in high-risk prostate cancer (PCa) and the indications for a surgical approach are expanding, even in cases of very high PSA or node-positive disease. We explored the outcomes of debulking surgery in the setting of these very high-risk PCa patients, in order to assess its feasibility. This review confirms the important role achieved by surgery in the complex setting of patients with very high-risk PCA. Excellent survival rates have been reported, even when PSA exceeds 100 ng/mL. The completion of RP with lymphadenectomy might give a survival benefit in patients who were found intraoperatively to be node-positive. Furthermore, salvage RP confirmed to be the most effective treatment option after RT failure. On the contrary, up-to-date surgery of isolated nodal recurrences has shown only little benefit. Finally, there is no evidence supporting the efficacy of debulking surgery in metastatic or in hormone-refractory tumours. An accurate selection of the patient is essential.
ISSN: 1464-4096
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Screening, Diagnostics and Biomarkers (-)
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science