Title: The role of adjuvant hormonal treatment after surgery for localized high-risk prostate cancer: results of a matched multiinstitutional analysis
Authors: Schubert, Maria ×
Joniau, Steven
Gontero, Paolo
Kneitz, Susanne
Scholz, Claus-Jürgen
Kneitz, Burkhard
Briganti, Alberto
Karnes, R Jeffrey
Tombal, Bertrand
Walz, Jochen
Hsu, Chao-Yu
Marchioro, Giansilvio
Bader, Pia
Bangma, Chris
Frohneberg, Detlef
Graefen, Markus
Schröder, Fritz
van Cangh, Paul
Van Poppel, Hendrik
Spahn, Martin #
Issue Date: 2012
Publisher: Hindawi Publishing Corp.
Series Title: Advances in Urology vol:2012
Article number: 612707
Abstract: Introduction. To assess the role of adjuvant androgen deprivation therapy (ADT) in high-risk prostate cancer patients (PCa) after surgery. Materials and Methods. The analysis case matched 172 high-risk PCa patients with positive section margins or non-organ confined disease and negative lymph nodes to receive adjuvant ADT (group 1, n = 86) or no adjuvant ADT (group 2, n = 86). Results. Only 11.6% of the patients died, 2.3% PCa related. Estimated 5-10-year clinical progression-free survival was 96.9% (94.3%) for group 1 and 73.7% (67.0%) for group 2, respectively. Subgroup analysis identified men with T2/T3a tumors at low-risk and T3b margins positive disease at higher risk for progression. Conclusion. Patients with T2/T3a tumors are at low-risk for metastatic disease and cancer-related death and do not need adjuvant ADT. We identified men with T3b margin positive disease at highest risk for clinical progression. These patients benefit from immediate adjuvant ADT.
ISSN: 1687-6369
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Screening, Diagnostics and Biomarkers (-)
× corresponding author
# (joint) last author

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