Title: Vitamin A and clefting: putative biological mechanisms
Authors: Ackermans, Mignon ×
Zhou, Huiqing
Carels, Carine
Wagener, Frank A D T G
Von den Hoff, Johannes W #
Issue Date: Oct-2011
Publisher: International Life Sciences Institute and Nutrition Foundation
Series Title: Nutrition Reviews vol:69 issue:10 pages:613-624
Article number: 10.1111/j.1753-4887.2011.00425.x
Abstract: Nutritional factors such as vitamin intake contribute to the etiology of cleft palate. Vitamin A is a regulator of embryonic development. Excess vitamin A can cause congenital malformations such as spina bifida and cleft palate. Therefore, preventive nutritional strategies are required. This review identifies putative biological mechanisms underlying the association between maternal vitamin A intake and cleft palate. Excessive vitamin A may disturb all three stages of palatogenesis: 1) during shelf outgrowth, it may decrease cell proliferation and thus prevent tissue development; 2) it may prevent shelf elevation by affecting extracellular matrix composition and hydration; and 3) during shelf fusion, it may affect epithelial differentiation and apoptosis, which precludes the formation of a continuous palate. In general, high doses of vitamin A affect palatogenesis through interference with cell proliferation and growth factors such as transforming growth factor β and platelet-derived growth factor. The effects of lower doses of vitamin A need to be investigated in greater depth in order to improve public health recommendations.
ISSN: 0029-6643
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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