The bantam microRNA is a target of the hippo tumor-suppressor pathway
Nolo, Riitta Morrison, Clayton M Tao, Chunyao Zhang, Xinwei Halder, Georg # ×
Current Biology Ltd.
Current Biology vol:16 issue:19 pages:1895-904
The Hippo tumor-suppressor pathway has emerged as a key signaling pathway that controls tissue size in Drosophila. Hippo signaling restricts tissue size by promoting apoptosis and cell-cycle arrest, and animals carrying clones of cells mutant for hippo develop severely overgrown adult structures. The Hippo pathway is thought to exert its effects by modulating gene expression through the phosphorylation of the transcriptional coactivator Yorkie. However, how Yorkie regulates growth, and thus the identities of downstream target genes that mediate the effects of Hippo signaling, are largely unknown.