Title: Concomitant oral tyrosine kinase inhibitors and bisphosphonates in advanced renal cell carcinoma with bone metastases
Authors: Beuselinck, Benoit ×
Wolter, Pascal
Karadimou, A
Elaidi, R
Dumez, Herlinde
Rogiers, Annelore
Van Cann, T
Willems, Ludo
Body, J-J
Berkers, Joost
Van Poppel, Hendrik
Lerut, Evelyne
Debruyne, P
Paridaens, Robert
Schöffski, Patrick #
Issue Date: Nov-2012
Publisher: Harcourt Publishers
Series Title: British Journal of Cancer vol:107 issue:10 pages:1665-1671
Abstract: Background:The presence of bone metastases in patients with metastatic renal cell carcinoma treated with oral tyrosine kinase inhibitors (TKIs) is associated with poorer outcome as compared with patients without bone involvement. Concomitant bisphosphonates could probably improve outcomes but also induce osteonecrosis of the jaw (ONJ).Methods:Retrospective study on all the renal cell carcinoma patients with bone metastases treated with sunitinib or sorafenib between November 2005 and June 2012 at the University Hospitals Leuven and AZ Groeninge in Kortrijk.Results:Seventy-six patients were included in the outcome analysis: 49 treated with concomitant bisphosphonates, 27 with TKI alone. Both groups were well balanced in terms of prognostic and predictive markers. Response rate (38% vs 16% partial responses, P=0.028), median progression-free survival (7.0 vs 4.0 months, P=0.0011) and median overall survival (17.0 vs 7.0 months, P=0.022) were significantly better in patients receiving bisphosphonates. The incidence of ONJ was 10% in patients treated with TKI and bisphosphonates.Conclusion:Concomitant use of bisphosphonates and TKI in renal cell carcinoma patients with bone involvement probably improves treatment efficacy, to be confirmed by prospective studies, but is associated with a high incidence of ONJ.
ISSN: 0007-0920
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Oncology
Screening, Diagnostics and Biomarkers (-)
Translational Cell & Tissue Research
Clinical Pharmacology and Pharmacotherapy
× corresponding author
# (joint) last author

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