Title: Optimized In Vivo Detection of Dopamine Release Using 18F-Fallypride PET
Authors: Ceccarini, Jenny ×
Vrieze, Elske
Koole, Michel
Muylle, Tom
Bormans, Guy
Claes, Stephan
Van Laere, Koen #
Issue Date: Oct-2012
Publisher: Society of Nuclear Medicine
Series Title: Journal of Nuclear Medicine vol:53 issue:10 pages:1565-72
Article number: 10.2967/jnumed.111.099416
Abstract: The high-affinity D(2/3) PET radioligand (18)F-fallypride offers the possibility of measuring both striatal and extrastriatal dopamine release during activation paradigms. When a single (18)F-fallypride scanning protocol is used, task timing is critical to the ability to explore both striatal and extrastriatal dopamine release simultaneously. We evaluated the sensitivity and optimal timing of task administration for a single (18)F-fallypride PET protocol and the linearized simplified reference region kinetic model in detecting both striatal and extrastriatal reward-induced dopamine release, using human and simulation studies.
ISSN: 0161-5505
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Nuclear Medicine & Molecular Imaging
Research Group Psychiatry
× corresponding author
# (joint) last author

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