Title: No association between striatal dopamine transporter binding and body mass index: A multi-center European study in healthy volunteers
Authors: van de Giessen, Elsmarieke ×
Hesse, Swen
Caan, Matthan W A
Zientek, Franziska
Dickson, John C
Tossici-Bolt, Livia
Sera, Terez
Asenbaum, Susanne
Guignard, Renaud
Akdemir, Umit O
Knudsen, Gitte M
Nobili, Flavio
Pagani, Marco
Vander Borght, Thierry
Van Laere, Koen
Varrone, Andrea
Tatsch, Klaus
Booij, Jan
Sabri, Osama #
Issue Date: 2013
Publisher: Academic Press
Series Title: NeuroImage vol:1 issue:64 pages:61-67
Article number: S1053-8119(12)00921-4
Abstract: INTRODUCTION: Dopamine is one among several neurotransmitters that regulate food intake and overeating. Thus, it has been linked to the pathophysiology of obesity and high body mass index (BMI). Striatal dopamine D(2) receptor availability is lower in obesity and there are indications that striatal dopamine transporter (DAT) availability is also decreased. In this study, we tested whether BMI and striatal DAT availability are associated. METHODS: The study included 123 healthy individuals from a large European multi-center database. They had a BMI range of 18.2-41.1kg/m(2) and were scanned using [(123)I]FP-CIT SPECT imaging. Scans were analyzed with both region-of-interest and voxel-based analysis to determine the binding potential for DAT availability in the caudate nucleus and putamen. A direct relation between BMI and DAT availability was assessed and groups with high and low BMI were compared for DAT availability. RESULTS: No association between BMI and striatal DAT availability was found. CONCLUSION: The lack of an association between BMI and striatal DAT availability suggests that the regulation of striatal synaptic dopamine levels by DAT plays no or a limited role in the pathophysiology of overweight and obesity.
ISSN: 1053-8119
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science