Antiretroviral therapy optimisation without genotype resistance testing: a perspective on treatment history based models
Prosperi, Mattia C F × Rosen-Zvi, Michal Altmann, André Zazzi, Maurizio Di Giambenedetto, Simona Kaiser, Rolf Schülter, Eugen Struck, Daniel Sloot, Peter van de Vijver, David A Vandamme, Anne-Mieke Sönnerborg, Anders EuResist study group Virolab study group #
Public Library of Sciene
PLoS One vol:5 issue:10 pages:e13753-e13753
Although genotypic resistance testing (GRT) is recommended to guide combination antiretroviral therapy (cART), funding and/or facilities to perform GRT may not be available in low to middle income countries. Since treatment history (TH) impacts response to subsequent therapy, we investigated a set of statistical learning models to optimise cART in the absence of GRT information.