Title: Phylogeography of dengue virus serotype 4, Brazil, 2010-2011
Authors: Nunes, Marcio Roberto Teixeira
Faria, Nuno Rodrigues ×
Vasconcelos, Helena Baldez
Medeiros, Daniele Barbosa de Almeida
Silva de Lima, Clayton Pereira
Carvalho, Valéria Lima
Pinto da Silva, Eliana Vieira
Cardoso, Jedson Ferreira
Sousa, Edivaldo Costa
Nunes, Keley Nascimento Barbosa
Rodrigues, Sueli Guerreiro
Abecasis, Ana Barroso
Suchard, Marc A
Lemey, Philippe
Vasconcelos, Pedro Fernando da Costa #
Issue Date: Nov-2012
Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC)
Series Title: Emerging Infectious Diseases vol:18 issue:11 pages:1858-1864
Article number: 10.3201/eid1811.120217
Abstract: Dengue virus serotype 4 (DENV-4) reemerged in Roraima State, Brazil, 28 years after it was last detected in the country in 1982. To study the origin and evolution of this reemergence, full-length sequences were obtained for 16 DENV-4 isolates from northern (Roraima, Amazonas, Pará States) and northeastern (Bahia State) Brazil during the 2010 and 2011 dengue virus seasons and for an isolate from the 1982 epidemic in Roraima. Spatiotemporal dynamics of DENV-4 introductions in Brazil were applied to envelope genes and full genomes by using Bayesian phylogeographic analyses. An introduction of genotype I into Brazil from Southeast Asia was confirmed, and full genome phylogeographic analyses revealed multiple introductions of DENV-4 genotype II in Brazil, providing evidence for >3 introductions of this genotype within the last decade: 2 from Venezuela to Roraima and 1 from Colombia to Amazonas. The phylogeographic analysis of full genome data has demonstrated the origins of DENV-4 throughout Brazil.
ISSN: 1080-6040
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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