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Title: Mutations selected in HIV-2-infected patients failing a regimen including atazanavir
Authors: Cavaco-Silva, Joana ×
Aleixo, Maria João
Van Laethem, Kristel
Faria, Domitília
Valadas, Emília
Gonçalves, Maria de Fátima
Gomes, Perpétua
Vandamme, Anne-Mieke
Cunha, Celso
Camacho, Ricardo Jorge
on behalf of the Portuguese HIV-2 Resistance Study Group #
Issue Date: Jan-2013
Publisher: Oxford University Press
Series Title: The Journal of Antimicrobial Chemotherapy vol:68 issue:1 pages:190-192
Abstract: OBJECTIVES: To investigate mutations selected in viruses from HIV-2-infected patients failing a highly active antiretroviral treatment (HAART) regimen including atazanavir/ritonavir. METHODS: Twenty-eight HIV-2-infected patients previously exposed to atazanavir/ritonavir and failing therapy were studied. The protease (PR) gene was amplified and sequenced, and mutations emerging under atazanavir/ritonavir selective pressure were reported. RESULTS: The I50L mutation emerged in 4 out of 28 HIV-2-infected patients failing a HAART regimen including atazanavir/ritonavir. Besides I50L, four PR mutations previously associated with protease inhibitor resistance (I54L, I64V, V71I and I82F) and six PR mutations of unknown impact (V10I, E37D, S43T, K45R, I75V and F85L) in HIV-2 were also identified in this small group of patients. CONCLUSIONS: Several mutations were associated with virological failure of a regimen including atazanavir/ritonavir in HIV-2-infected patients, including I50L for the first time. It should be included in HIV-2 algorithms for interpretation of genotypic resistance data, and taken into account when making therapeutic decisions for HIV-2-infected patients.
URI: 
ISSN: 0305-7453
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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