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Title: H63D polymorphism in HFE is not associated with amyotrophic lateral sclerosis
Authors: van Rheenen, Wouter ×
Diekstra, Frank P
van Doormaal, Perry T C
Seelen, Meinie
Kenna, Kevin
McLaughlin, Russell
Shatunov, Aleksey
Czell, David
van Es, Michael A
van Vught, Paul W J
Van Damme, Philip
Smith, Bradley N
Waibel, Stefan
Schelhaas, H Jurgen
van der Kooi, Anneke J
de Visser, Marianne
Weber, Markus
Robberecht, Wim
Hardiman, Orla
Shaw, Pamela J
Shaw, Christopher E
Morrison, Karen E
Al-Chalabi, Ammar
Andersen, Peter M
Ludolph, Albert C
Veldink, Jan H
van den Berg, Leonard H #
Issue Date: May-2013
Publisher: Elsevier
Series Title: Neurobiology of aging vol:34 issue:5 pages:1517.e5-7
Article number: S0197-4580(12)00472-1
Abstract: The H63D polymorphism in HFE has frequently been associated with susceptibility to amyotrophic lateral sclerosis (ALS). Regarding the role of HFE in iron homeostasis, iron accumulation is considered an important process in ALS. Furthermore, novel therapeutic strategies are being developed targeting this process. Evidence for this genetic association is, however, limited to several small studies. For this reason we studied the H63D polymorphism in a large European cohort including 3962 ALS patients and 5072 control subjects from 7 countries. After meta-analysis of previous studies and current findings we conclude that the H63D polymorphism in HFE is not associated with susceptibility to ALS, age at disease onset, or survival.
URI: 
ISSN: 0197-4580
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Neurobiology (Vesalius Research Center)
× corresponding author
# (joint) last author

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