Title: Implications for the mammalian sialidases in the physiopathology of skeletal muscle
Authors: Fanzani, Alessandro ×
Zanola, Alessandra
Faggi, Fiorella
Papini, Nadia
Venerando, Bruno
Tettamanti, Guido
Sampaolesi, Maurilio
Monti, Eugenio #
Issue Date: Nov-2012
Publisher: BioMed Central Ltd.
Series Title: Skeletal Muscle vol:2 issue:1
Article number: 23
Abstract: ABSTRACT: The family of mammalian sialidases is composed of four distinct versatile enzymes that remove negatively charged terminal sialic acid residues from gangliosides and glycoproteins in different subcellular areas and organelles, including lysosomes, cytosol, plasma membrane and mitochondria. In this review we summarize the growing body of data describing the important role of sialidases in skeletal muscle, a complex apparatus involved in numerous key functions and whose functional integrity can be affected by various conditions, such as aging, chronic diseases, cancer and neuromuscular disorders. In addition to supporting the proper catabolism of glycoconjugates, sialidases can affect different signaling pathways by desialylation of many receptors and modulation of ganglioside content in cell membranes, thus actively participating in myoblast proliferation, differentiation and hypertrophy, insulin responsiveness and skeletal muscle architecture.
ISSN: 2044-5040
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Embryo and Stemcells (-)
× corresponding author
# (joint) last author

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