Title: Toward an early marker of metabolic dysfunction: omentin-1 in prepubertal children
Authors: Prats-Puig, Anna ×
Bassols, Judit
Bargalló, Eva
Mas-Parareda, Marta
Ribot, Rosa
Soriano-Rodríguez, Pilar
Berengüí, Àngela
Díaz, Marta
de Zegher, Francis
Ibánez, Lourdes
López-Bermejo, Abel #
Issue Date: Sep-2011
Publisher: NAASO, The Obesity Society
Series Title: Obesity vol:19 issue:9 pages:1905-7
Article number: 10.1038/oby.2011.198
Abstract: Omentin-1 is a recently recognized adipokine primarily originating in visceral adipose tissue. We posited that circulating omentin-1 could be an early marker of metabolic dysfunction. To this end, we examined the associations between circulating omentin-1, body fat (bioelectric impedance), an endocrine-metabolic profile (homeostasis model assessment for insulin resistance (HOMA(IR)), serum lipids, high-molecular-weight (HMW) adiponectin and blood pressure (BP)) and family history of obesity and diabetes in asymptomatic prepubertal children (n = 161; 77 boys and 84 girls; age 7 ± 1 year) with a normal distribution of height and weight. Increased circulating omentin-1 was associated with a poorer metabolic profile, with relatively higher HOMA(IR), fasting triacylglycerol, BP and familial prevalence of diabetes (all P < 0.005 to P < 0.0001), and relatively lower fraction of HMW adiponectin (P < 0.005), whereas no relationship was found with body weight or fat or with family history of obesity. All these associations were independent of age, gender and fat mass. In conclusion, circulating omentin-1 may become a marker of metabolic dysfunction integrating insulin sensitivity, markers of adipose-tissue metabolism and BP as early as in prepubertal childhood.
ISSN: 1930-7381
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Screening, Diagnostics and Biomarkers (-)
× corresponding author
# (joint) last author

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