Title: On metformin's potential to prevent preterm delivery in women with polycystic ovary syndrome - an epi-analysis
Authors: Vanky, Eszter ×
de Zegher, Francis
Díaz, Marta
Ibáñez, Lourdes
Carlsen, Sven M #
Issue Date: Dec-2012
Publisher: Munksgaard
Series Title: Acta Obstetricia et Gynecologica Scandinavica vol:91 issue:12 pages:1460-1464
Article number: 10.1111/aogs.12015
Abstract: Our aim was to reevaluate if metformin may reduce late miscarriage/preterm delivery, preeclampsia and gestational diabetes in women with polycystic ovary syndrome (PCOS). We performed an epi-analysis of two randomized controlled trials. The participants were 313 PCOS women with singleton pregnancies, aged 18-42 years. They were randomized to metformin or placebo treatment from first trimester until delivery. We analyzed the prevalence of late miscarriage/ preterm delivery, preeclampsia and gestational diabetes both according intention-to-treat principal and per protocol analysis. The metformin-treated patients had less late miscarriage/preterm delivery; 5 (3%) vs. 18 (11%) in the placebo group (p<0.01). There was no difference in the prevalence of gestational diabetes and preeclampsia between the metformin and the placebo group. In this epi-analysis, metformin treatment during pregnancy seems to reduce early delivery in women with PCOS. We believe further randomized studies should be performed, before firm conclusions can be drawn.
ISSN: 0001-6349
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Screening, Diagnostics and Biomarkers (-)
× corresponding author
# (joint) last author

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