Acta Obstetricia et Gynecologica Scandinavica vol:91 issue:12 pages:1460-1464
Our aim was to reevaluate if metformin may reduce late miscarriage/preterm delivery, preeclampsia and gestational diabetes in women with polycystic ovary syndrome (PCOS). We performed an epi-analysis of two randomized controlled trials. The participants were 313 PCOS women with singleton pregnancies, aged 18-42 years. They were randomized to metformin or placebo treatment from first trimester until delivery. We analyzed the prevalence of late miscarriage/ preterm delivery, preeclampsia and gestational diabetes both according intention-to-treat principal and per protocol analysis. The metformin-treated patients had less late miscarriage/preterm delivery; 5 (3%) vs. 18 (11%) in the placebo group (p<0.01). There was no difference in the prevalence of gestational diabetes and preeclampsia between the metformin and the placebo group. In this epi-analysis, metformin treatment during pregnancy seems to reduce early delivery in women with PCOS. We believe further randomized studies should be performed, before firm conclusions can be drawn.