Title: Neural Implants Containing a Resorbable Chitosan Matrix
Authors: Ceyssens, Frederik
van Kuyck, Kris
Nuttin, Bart
Puers, Robert
Issue Date: 2012
Publisher: Elsevier
Host Document: Procedia Engineering vol:47 pages:688-689
Conference: Eurosensors edition:26 location:Krakow date:9-12 September 2012
Abstract: We have developed a novel type of neural electrode array for future brain-machine interfaces (BMIs) or
neural prosthesis requiring high resolution recording and stimulation on the cortex. The microelectrode
arrays developed comprise of a thin film stack of platinum and polyimide or Parylene C insulation, which is
finely microstructured for increased flexibility. The electrode stack is temporarily reinforced with a matrix of
porous chitosan, which resorbs after implantation.
This design ensures low invasiveness and mechanical irritation during prolonged use, while the chitosan
matrix ensures the implant is stiff enough for practical handling during the implantation procedure and is
resorbed afterwards. Furthermore, it adds haemostatic and antiseptic properties to the implant. The design
and fabrication process are presented. In vitro and long-term in vivo test results are shown, showing the
suitability for the application targeted.
ISSN: 1877-7058
Publication status: published
KU Leuven publication type: IC
Appears in Collections:ESAT - MICAS, Microelectronics and Sensors
Research Group Experimental Neurosurgery and Neuroanatomy

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