Title: Standardisation of EGFR FISH in colorectal cancer: results of an international interlaboratory reproducibility ring study
Authors: Sartore-Bianchi, Andrea ×
Fieuws, Steffen
Veronese, Silvio
Moroni, Mauro
Personeni, Nicola
Frattini, Milo
Torri, Valter
Cappuzzo, Federico
Vander Borght, Sara
Martin, Vittoria
Skokan, Margaret
Santoro, Armando
Gambacorta, Marcello
Tejpar, Sabine
Varella-Garcia, Marileila
Siena, Salvatore #
Issue Date: Mar-2012
Publisher: British Medical Journal Publishing Group
Series Title: Journal of Clinical Pathology vol:65 issue:3 pages:218-223
Abstract: Epidermal growth factor receptor (EGFR) gene copy number evaluated by fluorescence in situ hybridisation (FISH) can discriminate among KRAS wild-type patients those with better outcome to EGFR-targeted therapy in metastatic colorectal cancer, further enhancing selection of patients. Nevertheless, enumeration of gene copies is challenging and the lack of analytical standardisation has limited incorporation of the test into the clinical practice. We therefore assessed EGFR FISH interlaboratory consensus among five molecular diagnostic reference centres.
ISSN: 0021-9746
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Digestive Oncology (+)
Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat)
× corresponding author
# (joint) last author

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