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Title: The mammalian gene function resource: the international knockout mouse consortium
Authors: Bradley, Allan ×
Anastassiadis, Konstantinos
Ayadi, Abdelkader
Battey, James F
Bell, Cindy
Birling, Marie-Christine
Bottomley, Joanna
Brown, Steve D
Bürger, Antje
Bult, Carol J
Bushell, Wendy
Collins, Francis S
Desaintes, Christian
Doe, Brendan
Economides, Aris
Eppig, Janan T
Finnell, Richard H
Fletcher, Colin
Fray, Martin
Frendewey, David
Friedel, Roland H
Grosveld, Frank G
Hansen, Jens
Hérault, Yann
Hicks, Geoffrey
Hörlein, Andreas
Houghton, Richard
Hrabé de Angelis, Martin
Huylebroeck, Danny
Iyer, Vivek
de Jong, Pieter J
Kadin, James A
Kaloff, Cornelia
Kennedy, Karen
Koutsourakis, Manousos
Kent Lloyd, K C
Marschall, Susan
Mason, Jeremy
McKerlie, Colin
McLeod, Michael P
von Melchner, Harald
Moore, Mark
Mujica, Alejandro O
Nagy, Andras
Nefedov, Mikhail
Nutter, Lauryl M
Pavlovic, Guillaume
Peterson, Jane L
Pollock, Jonathan
Ramirez-Solis, Ramiro
Rancourt, Derrick E
Raspa, Marcello
Remacle, Jacques E
Ringwald, Martin
Rosen, Barry
Rosenthal, Nadia
Rossant, Janet
Ruiz Noppinger, Patricia
Ryder, Ed
Schick, Joel Zupicich
Schnütgen, Frank
Schofield, Paul
Seisenberger, Claudia
Selloum, Mohammed
Simpson, Elizabeth M
Skarnes, William C
Smedley, Damian
Stanford, William L
Francis Stewart, A
Stone, Kevin
Swan, Kate
Tadepally, Hamsa
Teboul, Lydia
Tocchini-Valentini, Glauco P
Valenzuela, David
West, Anthony P
Yamamura, Ken-Ichi
Yoshinaga, Yuko
Wurst, Wolfgang #
Issue Date: Oct-2012
Publisher: Springer-Verlag
Series Title: Mammalian Genome vol:23 issue:9-10 pages:580-586
Abstract: In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed high-throughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal ( www.knockoutmouse.org ) has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.
URI: 
ISSN: 0938-8990
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Embryo and Stemcells (-)
× corresponding author
# (joint) last author

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