Title: Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
Authors: Melum, Espen ×
Franke, Andre
Schramm, Christoph
Weismüller, Tobias J
Gotthardt, Daniel Nils
Offner, Felix A
Juran, Brian D
Laerdahl, Jon K
Labi, Verena
Björnsson, Einar
Weersma, Rinse K
Henckaerts, Liesbet
Teufel, Andreas
Rust, Christian
Ellinghaus, Eva
Balschun, Tobias
Boberg, Kirsten Muri
Ellinghaus, David
Bergquist, Annika
Sauer, Peter
Ryu, Euijung
Hov, Johannes Roksund
Wedemeyer, Jochen
Lindkvist, Björn
Wittig, Michael
Porte, Robert J
Holm, Kristian
Gieger, Christian
Wichmann, H-Erich
Stokkers, Pieter
Ponsioen, Cyriel Y
Runz, Heiko
Stiehl, Adolf
Wijmenga, Cisca
Sterneck, Martina
Vermeire, Severine
Beuers, Ulrich
Villunger, Andreas
Schrumpf, Erik
Lazaridis, Konstantinos N
Manns, Michael P
Schreiber, Stefan
Karlsen, Tom H #
Issue Date: Jan-2011
Publisher: Nature Publishing Group
Series Title: Nature Genetics vol:43 issue:1 pages:17-9
Abstract: Primary sclerosing cholangitis (PSC) is a chronic bile duct disease affecting 2.4-7.5% of individuals with inflammatory bowel disease. We performed a genome-wide association analysis of 2,466,182 SNPs in 715 individuals with PSC and 2,962 controls, followed by replication in 1,025 PSC cases and 2,174 controls. We detected non-HLA associations at rs3197999 in MST1 and rs6720394 near BCL2L11 (combined P = 1.1 × 10⁻¹⁶ and P = 4.1 × 10⁻⁸, respectively).
ISSN: 1061-4036
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
Department of Microbiology & Immunology - miscellaneous
× corresponding author
# (joint) last author

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