Title: Evidence for the importance of iron in the alpha-oxidation of 3-methyl-substituted fatty-acids in the intact cell
Authors: Croes, K
Casteels, Minne
Van Veldhoven, Paul P
Mannaerts, Guy # ×
Issue Date: Jan-1995
Publisher: Elsevier science bv
Series Title: Biochimica et biophysica acta-lipids and lipid metabolism vol:1255 issue:1 pages:63-67
Abstract: Preincubation of isolated rat hepatocytes with desferrioxamine or o-phenanthroline, two iron-specific chelators, strongly suppressed the CO2-production from the alpha-oxidation of 3-methylmargaric acid, whereas the beta-oxidation of 2-methylpalmitic acid, palmitic acid, trihydroxycoprostanic acid and the conversion of formic acid to CO2 were not affected. When, after the initial preincubation with the chelators and prior to the addition of 3-methylmargaric acid, iron-saturated transferrin and Fe3+ were added, a partial restitution of the CO2-production rates was obtained. These facts provide further evidence for the importance of iron in the alpha-oxidation of 3-methyl-substituted fatty acids.
ISSN: 0005-2760
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmacology Section (-)
Laboratory of Lipid Biochemistry and Protein Interactions
Department of Pharmaceutical & Pharmacological Sciences - miscellaneous
× corresponding author
# (joint) last author

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