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Title: Full-length genomic analysis of porcine G9P[23] and G9P[7] rotavirus strains isolated from pigs with diarrhea in South Korea
Authors: Kim, Ha-Hyun
Matthijnssens, Jelle ×
Kim, Hyun-Jeong
Kwon, Hyung-Jun
Park, Jun-Gyu
Son, Kyu-Yeol
Ryu, Eun-Hye
Kim, Deok-Song
Lee, Woo Song
Kang, Mun-Il
Yang, Dong-Kun
Hyun, Bang-Hun
Park, Sang-Ik
Park, Su-Jin
Cho, Kyoung-Oh #
Issue Date: Oct-2012
Publisher: Elsevier Science
Series Title: Infection, Genetics and Evolution vol:12 issue:7 pages:1427-1435
Abstract: Group A rotaviruses (RVAs) are agents causing severe gastroenteritis in infants and young animals. G9 RVA strains are believed to have originated from pigs. However, this genotype has emerged as the fifth major human RVA genotype worldwide. To better understand the relationship between human and porcine RVA strains, complete RVA genome data are needed. For human RVA strains, the number of complete genome data have grown exponentially. However, there is still a lack of complete genome data on porcine RVA strains. Recently, G9 RVA strains have been identified as the third most important genotype in diarrheic pigs in South Korea in combinations with P[7] and P[23]. This study is the first report on complete genome analyses of 1 G9P[7] and 3 G9P[23] porcine RVA strains, resulting in the following genotype constellation: G9–P[7]/P[23]–I5–R1–C1–M1–A8–N1–T1–E1–H1. By comparisons of these genotype constellations, it was revealed that the Korean G9P[7] and G9P[23] RVA strains possessed a typical porcine RVA backbone, similar to other known porcine RVA strains. However, detailed phylogenetic analyses revealed the presence of intra-genotype reassortments among porcine RVA strains in South Korea. Thus, our data provide genetic information of G9 RVA strains increasingly detected in both humans and pigs, and will help to establish the role of pigs as a source or reservoir for novel human RVA strains.
ISSN: 1567-1348
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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