Title: Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: Pooled analysis of the CRYSTAL and OPUS randomised clinical trials
Authors: Bokemeyer, Carsten ×
Van Cutsem, Eric
Rougier, Philippe
Ciardiello, Fortunato
Heeger, Steffen
Schlichting, Michael
Celik, Ilhan
Köhne, Claus-Henning #
Issue Date: Jul-2012
Publisher: Pergamon
Series Title: European Journal of Cancer vol:48 issue:10 pages:1466-1475
Abstract: The CRYSTAL and OPUS randomised clinical trials demonstrated that adding cetuximab to first-line chemotherapy in patients with KRAS wild-type metastatic colorectal cancer (mCRC) significantly improved treatment outcome compared with chemotherapy alone. The objective of this pooled analysis was to further investigate these findings in patients with KRAS wild-type tumours using extended survival data and following an enhancement in the ascertainment rate of KRAS and BRAF tumour mutation status from these studies.
ISSN: 0959-8049
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Digestive Oncology (+)
× corresponding author
# (joint) last author

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