Title: VP6-sequence-based cutoff values as a criterion for rotavirus species demarcation
Authors: Matthijnssens, Jelle ×
Otto, Peter H
Ciarlet, Max
Desselberger, Ulrich
Van Ranst, Marc
Johne, Reimar #
Issue Date: Jun-2012
Publisher: Springer-Verlag
Series Title: Archives of Virology vol:157 issue:6 pages:1177-1182
Abstract: Indirect immunofluorescence techniques targeting the rotavirus (RV) protein VP6 are used to differentiate RV species. The ICTV recognizes RV species A to E and two tentative species, F and G. A potential new RV species, ADRV-N, has been described. Phylogenetic trees and pairwise identity frequency graphs were constructed with more than 400 available VP6 sequences and seven newly determined VP6 sequences of RVD strains. All RV species were separated into distinct phylogenetic clusters. An amino acid sequence cutoff value of 53% firmly permitted differentiation of RV species, and ADRV-N was tentatively assigned to a novel RV species H (RVH).
ISSN: 0304-8608
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science