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Title: Complete genetic characterization of human G2P[6] and G3P[6] rotavirus strains
Authors: Heylen, Elisabeth
Zeller, Mark
Ciarlet, Max
De Coster, Sarah
Van Ranst, Marc
Matthijnssens, Jelle # ×
Issue Date: Jan-2013
Publisher: Elsevier Science
Series Title: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases vol:13 pages:27-35
Article number: S1567-1348(12)00288-2
Abstract: During the 2008-2009 rotavirus season, 10 G3P[6] rotavirus strains were isolated for the first time in Belgium, while an outbreak of G2P[6] strains occurred in the USA in 2005-2006. Partial sequencing of the 11 genome segments of the 10 Belgian G3P[6] strains revealed a clonal origin. Two of these strains, and a G2P[6] strain representative of the American outbreak, were selected and sequenced completely to analyze their evolutionary relationships. Genetic analysis revealed that all strains possessed a DS-1-like genotype constellation. The 2 Belgian G3P[6] strains showed >99% sequence identity at the nucleotide level and the American G2P[6] strain was phylogenetically closely related to the Belgian P[6] strains. These data suggest that reassortment(s) involving VP7 occurred recently, and that the prevalence of DS-1-like P[6] rotavirus strains need to be closely monitored because the currently licensed RVA vaccines contain neither the P[6] genotype nor strains with a complete human DS-1 genotype constellation.
URI: 
ISSN: 1567-1348
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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