Title: Interpreting Breast International Group (BIG) 1-98: a randomized, double-blind, phase III trial comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with hormone receptor-positive, early breast cancer
Authors: Regan, M M ×
Price, K N
Giobbie-Hurder, A
Thürlimann, B
Gelber, R D
International Breast Cancer Study Group
BIG 1-98 Collaborative Group #
Contributors: Paridaens, Robert
Issue Date: 26-May-2011
Publisher: Biomed Central Ltd
Series Title: Breast Cancer Research vol:13 issue:3 pages:209-209
Abstract: The Breast International Group (BIG) 1-98 study is a four-arm trial comparing 5 years of monotherapy with tamoxifen or with letrozole or with sequences of 2 years of one followed by 3 years of the other for postmenopausal women with endocrine-responsive early invasive breast cancer. From 1998 to 2003, BIG -98 enrolled 8,010 women. The enhanced design f the trial enabled two complementary analyses of efficacy and safety. Collection of tumor specimens further enabled treatment comparisons based on tumor biology. Reports of BIG 1-98 should be interpreted in relation to each individual patient as she weighs the costs and benefits of available treatments.
ISSN: 1465-542X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Oncology
× corresponding author
# (joint) last author

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