Title: Production of formyl-CoA during peroxisomal alpha-oxidation of 3-methyl-branched fatty acids
Authors: Croes, K ×
Van Veldhoven, Paul P
Mannaerts, Guy
Casteels, Minne #
Issue Date: Jan-1997
Publisher: Elsevier science bv
Series Title: FEBS Letters vol:407 issue:2 pages:197-200
Abstract: alpha-Oxidation of 3-methyl-substituted fatty acids was studied in purified rat liver peroxisomes. The experiments revealed that formyl-CoA is formed during the alpha-oxidation process, The amount of formyl-CoA found constituted 2-5% of the amount of formate formed. Under the conditions used, no activation of exogenously added formate occurred in purified peroxisomes, whereas 95.5% of added synthetic formyl-CoA was converted to formate, These data indicate that during alpha-oxidation first formyl-CoA is formed, which is then hydrolysed to formate. (C) 1997 Federation of European Biochemical Societies.
ISSN: 0014-5793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmacology Section (-)
Laboratory of Lipid Biochemistry and Protein Interactions
Department of Pharmaceutical & Pharmacological Sciences - miscellaneous
× corresponding author
# (joint) last author

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