Title: Chemotherapy during pregnancy: effect of anthracyclines on fetal and maternal cardiac function
Authors: Mhallem Gziri, Mina
Debiève, Frédéric
De Catte, Luc
Mertens, Luc
Barrea, Catherine
Van Calsteren, Kristel
Han, Sileny N
Heyns, Liesbeth
Amant, Frédéric # ×
Issue Date: Dec-2012
Publisher: Munksgaard
Series Title: Acta Obstetricia et Gynecologica Scandinavica vol:91 issue:12 pages:1465-1468
Article number: 10.1111/j.1600-0412.2012.01524.x
Abstract: Chemotherapy and especially anthracyclines are associated to cardiotoxicity. To assess this potential risk during pregnancy a clinical case-control trial was conducted. Maternal cardiac function, fetal Doppler and fetal cardiac function were evaluated before and after chemotherapy. Maternal cardiac function was assessed by echocardiography before and after the third cycle of anthracyclines and compared to a control group of 10 non-pregnant women matched for age, type of cancer and anthracycline treatment. Ten fetuses exposed to chemotherapy were compared to 10 control fetuses matched for gestational age and gender. Biometry, amniotic fluid index, fetal Doppler and cardiac function were assessed before and after each cycle of chemotherapy. Hundred and eight fetal ultrasounds scans were performed before and after 36 cycles of chemotherapy. Anthracycline exposure did not result in acute maternal and fetal cardiac dysfunction in this small cohort study.
ISSN: 0001-6349
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gynaecological Oncology
Department of Development and Regeneration - miscellaneous (+)
× corresponding author
# (joint) last author

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