Title: Highlights of the EORTC St. Gallen International Expert Consensus on the primary therapy of gastric, gastroesophageal and oesophageal cancer - Differential treatment strategies for subtypes of early gastroesophageal cancer
Authors: Lutz, Manfred P ×
Zalcberg, John R
Ducreux, Michel
Ajani, Jaffer A
Allum, William
Aust, Daniela
Bang, Yung-Jue
Cascinu, Stefano
Hölscher, Arnulf
Jankowski, Janusz
Jansen, Edwin P M
Kisslich, Ralf
Lordick, Florian
Mariette, Christophe
Moehler, Markus
Oyama, Tsuneo
Roth, Arnaud
Rueschoff, Josef
Ruhstaller, Thomas
Seruca, Raquel
Stahl, Michael
Sterzing, Florian
Van Cutsem, Eric
van der Gaast, Ate
van Lanschot, Jan
Ychou, Marc
Otto, Florian #
Issue Date: Nov-2012
Publisher: Pergamon
Series Title: European Journal of Cancer vol:48 issue:16 pages:2941-2953
Abstract: The 1st St. Gallen EORTC Gastrointestinal Cancer Conference 2012 Expert Panel clearly differentiated treatment and staging recommendations for the various gastroesophageal cancers. For locally advanced gastric cancer (⩾T3N+), the preferred treatment modality was pre- and postoperative chemotherapy. The majority of panel members would also treat T2N+ or even T2N0 tumours with a similar approach mainly because pretherapeutic staging was considered highly unreliable. It was agreed that adenocarcinoma of the gastroesophageal junction (AEG) is classified best according to Siewert et al. Preoperative radiochemotherapy (RCT) is the preferred treatment for AEG type I and II tumours. For AEG type III, i.e. tumours which may be considered as gastric cancer, perioperative chemotherapy is the majority approach. For resectable squamous cell cancer of the oesophagus a clear majority recommended radiochemotherapy followed by surgery as optimal approach, irrespective of tumour size. In contrast, definitive RCT was judged appropriate for advanced tumours with extended lymph node involvement (N2) or for cancers of the upper oesophagus. Additional recommendations are presented on the use of endosonography, PET-CT scan and laparoscopy for staging and on the preferred approach to surgery.
ISSN: 0959-8049
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Digestive Oncology (+)
× corresponding author
# (joint) last author

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