Title: The nuclear envelope localization of DYT1 dystonia torsinA-ΔE requires the SUN1 LINC complex component
Authors: Jungwirth, Michael T
Kumar, Dhivya
Jeong, Danielle Y
Goodchild, Rose # ×
Issue Date: 31-May-2011
Publisher: BioMed Central
Series Title: BMC Cell Biology vol:12 pages:24-36
Abstract: DYT1 dystonia is an autosomal dominant neurological condition caused by a mutation that removes a single glutamic acid residue (ΔE) from the torsinA (torA) AAA+ protein. TorA appears to possess a nuclear envelope (NE) localized activity that requires Lamina-Associated-Polypeptide 1 (LAP1), which is an inner nuclear membrane localized torA-binding partner. Although hypoactive, the DYT1 dystonia torA-ΔE isoform often concentrates in the NE, suggesting that torA-ΔE also interacts with an NE-localized binding partner.
ISSN: 1471-2121
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science