Title: PlGF: a multitasking cytokine with disease-restricted activity
Authors: Dewerchin, Mieke
Carmeliet, Peter # ×
Issue Date: 2012
Series Title: Cold Spring Harbor perspectives in medicine vol:2 issue:8
Article number: 10.1101/cshperspect.a011056
Abstract: Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family that also comprises VEGF-A (VEGF), VEGF-B, VEGF-C, and VEGF-D. Unlike VEGF, PlGF is dispensable for development and health but has diverse nonredundant roles in tissue ischemia, malignancy, inflammation, and multiple other diseases. Genetic and pharmacological gain-of-function and loss-of-function studies have identified molecular mechanisms of this multitasking cytokine and characterized the therapeutic potential of delivering or blocking PlGF for various disorders.
ISSN: 2157-1422
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Angiogenesis and Vascular Metabolism (VIB-KU Leuven Centre for Cancer Biology) (+)
× corresponding author
# (joint) last author

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