Title: Regulated granule trafficking in platelets and neurons: A common molecular machinery
Authors: Goubau, Christophe ×
Buyse, Gunnar
Di Michele, Michela
Van Geet, Chris
Freson, Kathleen #
Issue Date: Aug-2013
Publisher: Saunders
Series Title: European Journal of Paediatric Neurology vol:17 issue:2 pages:117-125
Article number:
Abstract: Platelet function in primary hemostasis involves the secretion of granules upon activation, providing the localized delivery of effector proteins at sites of vascular injury. The sequential process of regulated secretion in platelets, from the biogenesis of the granules, through their transport and up to the exocytotic fusion process at the acceptor membrane, involves a complex molecular machinery conserved between some other specialized cells such as neurons. Mutations in genes encoding proteins involved in this process of granule trafficking have helped towards demystification of the underlying secretory mechanisms. Human diseases of trafficking encompass a broad symptomatology including a platelet-related bleeding diathesis and neuronal problems. In this review, we want to highlight the similarities in granule biology between platelets and neurons and further focus on some granule trafficking disorders that result in bleeding and neuropathology. This review provides evidence that platelet research can be expanded from traditional studies of isolated thrombopathies to the field of neuropathologies that include a platelet secretion defect.
ISSN: 1090-3798
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Neuro-musculo-skeletal Research (-)
Molecular and Vascular Biology
× corresponding author
# (joint) last author

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