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Title: An increased rate of falling leads to a rise in fracture risk in postmenopausal women with self-reported osteoarthritis: a prospective multinational cohort study (GLOW)
Authors: Prieto-Alhambra, Daniel ×
Nogues, Xavier
Javaid, M Kassim
Wyman, Allison
Arden, Nigel K
Azagra, Rafael
Cooper, Cyrus
Adachi, Jonathan D
Boonen, Steven
Chapurlat, Roland D
Compston, Juliet E
Gehlbach, Stephen H
Greenspan, Susan L
Hooven, Frederick H
Netelenbos, J Coen
Pfeilschifter, Johannes
Rossini, Maurizio
Sambrook, Philip N
Silverman, Stuart
Siris, Ethel S
Watts, Nelson B
Díez-Pérez, Adolfo #
Issue Date: Jun-2013
Publisher: H.K. Lewis
Series Title: Annals of the rheumatic diseases vol:72 issue:6 pages:911-7
Abstract: OBJECTIVES: Patients with osteoarthritis have increased bone mass but no decrease in fractures. The association between self-reported osteoarthritis and incident falls and fractures was studied in postmenopausal women. METHODS: The Global Longitudinal Study of Osteoporosis in Women is a prospective multinational cohort of 60 393 non-institutionalised women aged ≥55 years who had visited primary care practices within the previous 2 years. Questionnaires were mailed at yearly intervals. Patients were classified as having osteoarthritis if they answered yes to the question, 'Has a doctor or other health provider ever said that you had osteoarthritis or degenerative joint disease?', and this was validated against primary care records in a subsample. Information on incident falls, fractures and covariates was self-reported. Cox and Poisson models were used for incident fractures and number of falls, respectively, to compute hazard ratios (HRs) and rate ratios (RRs) for baseline osteoarthritis status. RESULTS: Of 51 386 women followed for a median of 2.9 years (interquartile range 2.1-3.0), 20 409 (40%) reported osteoarthritis. The adjusted HR for osteoarthritis predicting fracture was 1.21 (95% CI 1.13 to 1.30; p<0.0001) and the adjusted RR for falls was 1.24 (95% CI 1.22 to 1.26; p<0.0001). However, the association between osteoarthritis and fracture was not significant after adjustment for incident falls (HR 1.06 (95% CI 0.98 to 1.15; p=0.13)). CONCLUSIONS: Postmenopausal women with self-reported osteoarthritis have a 20% increased risk of fracture and experience 25% more falls than those without osteoarthritis. These data suggest that increased falls are the causal pathway of the association between osteoarthritis and fractures.
ISSN: 0003-4967
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gerontology and Geriatrics
× corresponding author
# (joint) last author

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