Title: Epidemiological evidence against a role for C-reactive protein causing leptin resistance
Authors: Rutter, Martin Kenneth ×
Sattar, Naveed
Tajar, Abdeloahid
O'Neill, Terence W
Lee, David M
Bartfai, Gyorgy
Boonen, Steven
Casanueva, Felipe F
Finn, Joseph D
Forti, Gianni
Giwercman, Aleksander
Han, Thang Sieu
Huhtaniemi, Ilpo
Kula, Krzysztof
Lean, Michael
Pendleton, Neil
Punab, Margus
Silman, Alan J
Vanderschueren, Dirk
Lowe, Gordon D
O'Rahilly, Stephen
Morris, Richard
Wu, Fredrick C W
Wannamethee, S Goya #
Issue Date: 2013
Publisher: BioScientifica Ltd.
Series Title: European Journal of Endocrinology vol:168 issue:1 pages:101-106
Abstract: OBJECTIVE: It has been suggested that elevated levels of C-reactive protein (CRP) might interfere with leptin signalling and contribute to leptin resistance. Our aim was to assess whether plasma levels of CRP influence leptin resistance in humans; and our hypothesis was that CRP levels would modify the cross-sectional relationships between leptin and measures of adiposity. DESIGN AND METHODS: We assessed 4 measures of adiposity: body mass index, waist circumference, fat mass, and % body fat in 2113 British Regional Heart Study (BRHS) men (mean (SD) age 69 (5) years), with replication in 760 (age 69 (6) years) European Male Aging Study (EMAS) subjects. RESULTS: In BRHS subjects leptin correlated with CRP (Spearman's r=0.22, p<0.0001). Leptin and CRP correlated with all 4 measures of adiposity (r-value range: 0.22 to 0.57, all p<0.0001). Age-adjusted mean levels for adiposity measures increased in relation to leptin levels; but CRP level did not consistently influence the β coefficients of the regression lines in a CRP-stratified analysis. In BRHS subjects, the BMI vs. leptin relationship demonstrated a weak statistical interaction with CRP (p=0.04). We observed no similar interaction in EMAS subjects, and no significant interactions with other measures of adiposity in BRHS or EMAS cohorts. CONCLUSION: We have shown that plasma CRP has little influence on the relationship between measures of adiposity and serum leptin levels in these middle-aged and elderly male European cohorts. This study provides epidemiological evidence against CRP having a significant role in causing leptin resistance.
ISSN: 0804-4643
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gerontology and Geriatrics
× corresponding author
# (joint) last author

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