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Title: The accuracy of positron emission tomography in the detection of posttransplant lymphoproliferative disorder
Authors: Dierickx, Daan * ×
Tousseyn, Thomas *
Requile', Annelies
Verscuren, Raf
Sagaert, Xavier
Morscio, Julie
Wlodarska, Iwona
Herreman, An
Kuypers, Dirk
Van Cleemput, Johan
Nevens, Frederik
Dupont, Lieven
Uyttebroeck, Anne
Pirenne, Jacques
Peeters, Chris
Verhoef, Gregor
Brepoels, Lieselot
Gheysens, Olivier #
Issue Date: May-2013
Publisher: Il Pensiero Scientifico
Series Title: Haematologica vol:98 issue:5 pages:771-775
Abstract: Background. We investigated sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 18F-fluorodeoxyglucose-positron emission tomography in 170 cases with suspected or biopsy-proven posttransplant lymphoproliferative disorder. Design and Methods. All solid organ and hematopoietic stem cell transplant recipients who underwent an 18F-fluorodeoxyglucose-positron emission tomography scan between 2003 and 2010 in our center for the indication posttransplant lymphoproliferative disorder, were retrospectively reviewed and results were compared with tissue biopsy, whenever possible. One hundred-seventy positron emission tomography-scans in hundred-fifty patients were eligible for evaluation. In 45 cases, the patient had a biopsy-confirmed posttransplant lymphoproliferative disorder before positron emission tomography scanning and positron emission tomography was performed for staging purposes. In the remaining 125 cases, positron emission tomography was performed to differentiate between posttransplant lymphoproliferative disorder and other diseases. 18F-fluorodeoxyglucose-uptake was quantitatively expressed by calculation of maximum and mean standardized uptake value in the most intense lesion, or, in the absence of attenuation corrected positron emission tomography scans by comparing uptake in target lesion to liver and mediastinal uptake. Results. We found an overall sensitivity of 89%, specificity of 89%, positive predictive value of 91% and negative predictive value of 87% for posttransplant lymphoproliferative disorder detection by 18F-fluorodeoxyglucose-positron emission tomography. In a subanalysis of the 125 scans performed for differentiating posttransplant lymphoproliferative disorder from other diseases, sensitivity, specificity, positive predictive value and negative predictive value were 90%, 89%, 85% and 93% respectively. 18F-fluorodeoxyglucose-uptake in posttransplant lymphoproliferative disorder was generally high with a median mean and maximum standardized uptake value of 9.0 [range 2.0-18.6] and 17.4 [range 2.6-26.4]. Posttransplant lymphoproliferative disorder often had an atypical presentation on positron emission tomography with high incidence of extranodal involvement. Conclusions. From these data, we can conclude that 18F-fluorodeoxyglucose-positron emission tomography is highly sensitive for detecting posttransplant lymphoproliferative disorder and has an excellent ability to differentiate posttransplant lymphoproliferative disorder from non-malignant diseases.
URI: 
ISSN: 0390-6078
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular Biology of Leukemia
Translational Cell & Tissue Research
Laboratory for Genetics of Malignant Disorders
Department of Human Genetics - miscellaneous
* (joint) first author
× corresponding author
# (joint) last author

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