Journal of Physiology-London vol:590 issue:Pt 17 pages:4321-33
Key points Acute changes in glycaemia can have substantial effects on gastro-intestinal motor function. A feeding state-related bistable memory system has been previously described in neurons of the hypothalamus. We found that peristaltic bowel movements are more pronounced in intestinal segments from re-fed compared to fasted animals and neuronal responses in the myenteric plexus are tuned to the feeding state, which illustrates that the feeding status remains imprinted ex vivo. This feeding state-related memory can be reproduced in vitro and humoral factors as well as glucose-dependent pathways are involved. Pharmacological manipulation of feeding state-specific signalling in enteric neurons can be of therapeutic importance in the treatment of motility-related feeding disorders.