Title: Specific hunger- and satiety-induced tuning of guinea pig enteric nerve activity
Authors: Roosen, Lina
Boesmans, Werend
Dondeyne, Marjan
Depoortere, Inge
Tack, Jan
Vanden Berghe, Pieter # ×
Issue Date: Sep-2012
Publisher: Cambridge University Press
Series Title: Journal of Physiology-London vol:590 issue:Pt 17 pages:4321-33
Article number: 10.1113/jphysiol.2012.231134
Abstract: Key points  Acute changes in glycaemia can have substantial effects on gastro-intestinal motor function.  A feeding state-related bistable memory system has been previously described in neurons of the hypothalamus.  We found that peristaltic bowel movements are more pronounced in intestinal segments from re-fed compared to fasted animals and neuronal responses in the myenteric plexus are tuned to the feeding state, which illustrates that the feeding status remains imprinted ex vivo.  This feeding state-related memory can be reproduced in vitro and humoral factors as well as glucose-dependent pathways are involved.  Pharmacological manipulation of feeding state-specific signalling in enteric neurons can be of therapeutic importance in the treatment of motility-related feeding disorders.
ISSN: 0022-3751
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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