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Title: Update on triple-negative breast cancer: prognosis and management strategies
Authors: Brouckaert, Olivier ×
Wildiers, Hans
Floris, Guiseppe
Neven, Patrick #
Issue Date: 2012
Publisher: Dove Medical Press Ltd.
Series Title: International Journal of Women's Health vol:4 pages:511-520
Article number: 10.2147/IJWH.S18541
Abstract: Triple negative breast cancer (TNBC) is a heterogeneous disease comprehending different orphan breast cancers simply defined by the absence of ER/PR/HER-2. Approximately 15%-20% of all breast cancers belong to this phenotype that has distinct risk factors, distinct molecular features, and a particular clinical presentation and outcome. All these features will be discussed in this review. The risk of developing TNBC varies with age, race, genetics, breastfeeding patterns, and parity. Some TNBC are very chemo-sensitive and the majority of patients confronted with and treated for TNBC will never relapse. Some (histological) subgroups of TNBC may have good prognosis even in the absence of chemotherapy. Distinct molecular subgroups within TNBC have been defined now as well. In case metastatic relapse occurs, this is usually within 5 years following surgery, and survival following metastatic relapse is shorter compared to other breast cancer subtypes; treatment options are few and responses lack durability. Novel drug targets and new biomarkers are needed to improve breast cancer care for patients presenting with TNBC. Further molecular/biological unraveling of TNBC is needed.
URI: 
ISSN: 1179-1411
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gynaecological Oncology
Translational Cell & Tissue Research
Laboratory of Experimental Oncology
× corresponding author
# (joint) last author

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