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Title: Measurement of elasticity and transepidermal water loss rate of burn scars with the Dermalab(®)
Authors: Anthonissen, Mieke ×
Daly, Daniel
Fieuws, Steffen
Massagé, Patrick
Van Brussel, Michel
Vranckx, Jan
Van den Kerckhove, Eric #
Issue Date: May-2013
Publisher: Butterworths
Series Title: Burns vol:39 issue:3 pages:420-428
Article number: S0305-4179(12)00249-5
Abstract: This cross-sectional study investigated the reproducibility of repeated elasticity and transepidermal water loss (TEWL) measurements with the DermaLab(®) on 32 active burn scars and healthy skin. Intra- and inter-observer reproducibility was examined by means of intra-class correlation coefficients (ICC) and standard error of measurements (SEM). Results showed good ICC values and rather high SEM values for inter- and intra-observer reproducibility of elasticity measurements. For TEWL measurements, ICC values were good and SEM values were high for inter- and intra-observer reproducibility. There was a significant difference between the estimated mean elasticity values of normal skin and grafted scars and between normal skin and spontaneously healed scars (p≤0.003). For the estimated mean TEWL values, there was a significant difference between normal skin and spontaneously healed scars (p=0.036). A significant negative relation was reported between mean TEWL and time after burn (p=0.008). In clinical trials it is necessary to interpret patient-specific changes in elasticity and TEWL with caution, since the SEMs of both modes are rather high. We therefore recommend the use of a mean of repeated measurements of elasticity and TEWL to decrease the SEM.
URI: 
ISSN: 0305-4179
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Physical Activity, Sports & Health Research Group
Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat)
× corresponding author
# (joint) last author

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