Title: Transduction of mechanical and cytoskeletal cues by YAP and TAZ
Authors: Halder, Georg ×
Dupont, Sirio
Piccolo, Stefano #
Issue Date: Sep-2012
Publisher: Nature Pub. Group
Series Title: Nature Reviews. Molecular Cell Biology vol:13 issue:9 pages:591-600
Article number: 10.1038/nrm3416
Abstract: The physical and mechanical properties of the cellular microenvironment regulate cell shape and can strongly influence cell fate. How mechanical cues are sensed and transduced to regulate gene expression has long remained elusive. Recently, cues from the extracellular matrix, cell adhesion sites, cell shape and the actomyosin cytoskeleton were found to converge on the regulation of the downstream effectors of the Hippo pathway YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif) in vertebrates and Yorkie in flies. This convergence may explain how mechanical signals can direct normal and pathological cell behaviour.
ISSN: 1471-0072
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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