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Title: Noninvasive molecular imaging of neuroinflammation
Authors: Jacobs, Andreas H ×
Tavitian, Bertrand
INMiND consortium
Contributors: Baekelandt, Veerle
Bormans, Guy
Van Laere, Koen
Issue Date: Jul-2012
Publisher: Lippincott Williams & Wilkins
Series Title: Journal of Cerebral Blood Flow and Metabolism vol:32 issue:7 pages:1393-1415
Article number: 10.1038/jcbfm.2012.53
Abstract: Inflammation is a highly dynamic and complex adaptive process to preserve and restore tissue homeostasis. Originally viewed as an immune-privileged organ, the central nervous system (CNS) is now recognized to have a constant interplay with the innate and the adaptive immune systems, where resident microglia and infiltrating immune cells from the periphery have important roles. Common diseases of the CNS, such as stroke, multiple sclerosis (MS), and neurodegeneration, elicit a neuroinflammatory response with the goal to limit the extent of the disease and to support repair and regeneration. However, various disease mechanisms lead to neuroinflammation (NI) contributing to the disease process itself. Molecular imaging is the method of choice to try to decipher key aspects of the dynamic interplay of various inducers, sensors, transducers, and effectors of the orchestrated inflammatory response in vivo in animal models and patients. Here, we review the basic principles of NI with emphasis on microglia and common neurologic disease mechanisms, the molecular targets which are being used and explored for imaging, and molecular imaging of NI in frequent neurologic diseases, such as stroke, MS, neurodegeneration, epilepsy, encephalitis, and gliomas.
URI: 
ISSN: 0271-678X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group for Neurobiology and Gene Therapy
Radiopharmacy
Nuclear Medicine & Molecular Imaging
× corresponding author

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