Title: Polycystins and cellular Ca(2+) signaling
Authors: Mekahli, Djalila
Parys, Jan
Bultynck, Geert
Missiaen, Ludwig
De Smedt, Humbert # ×
Issue Date: Aug-2013
Publisher: Birkhäuser Verlag
Series Title: Cellular and Molecular Life Sciences vol:70 issue:15 pages:2697-2712
Abstract: The cystic phenotype in autosomal dominant polycystic kidney disease is characterized by a profound dysfunction of many cellular signaling patterns, ultimately leading to an increase in both cell proliferation and apoptotic cell death. Disturbance of normal cellular Ca(2+) signaling seems to be a primary event and is clearly involved in many pathways that may lead to both types of cellular responses. In this review, we summarize the current knowledge about the molecular and functional interactions between polycystins and multiple components of the cellular Ca(2+)-signaling machinery. In addition, we discuss the relevant downstream responses of the changed Ca(2+) signaling that ultimately lead to increased proliferation and increased apoptosis as observed in many cystic cell types.
ISSN: 1420-682X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular and Cellular Signaling
× corresponding author
# (joint) last author

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