Title: Identification of fungicidal 2,6-disubstituted quinolines with Candida antibiofilm activity
Authors: Delattin, Nicolas
Bardiot, Dorothée
Marchand, Arnaud
Chaltin, Patrick
De Brucker, Katrijn
Cammue, Bruno ×
Thevissen, Karin #
Issue Date: 2012
Series Title: Molecules vol:17 issue:10 pages:12243-12251
Abstract: We identified two subseries of 2,6-disubstituted quinolines, consisting of 6-amide and 6-urea derivatives, which are characterized by fungicidal activity against
Candida albicans with minimal fungicidal concentration (MFC) < 15 μM. The 6-amide derivatives displayed the highest fungicidal activity against C. albicans, in particular compounds 737, 742 and 744 characterized by MFC values of 6.25 - 12.5 μM. Compounds 737 and 742 of this series displayed fungicidal activity against the emerging pathogen Candida glabrata (MFC < 50 μM). The 6-amide derivatives 737, 738, 742, and 744 and the 6-urea derivatives 798, 803, 804 and 807 could eradicate C. albicans biofilms. We found that the 6-urea derivatives 798, 804, and 807 induced accumulation of endogenous reactive oxygen species in Candida albicans biofilms.
ISSN: 1420-3049
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre of Microbial and Plant Genetics
Intellectual Property
× corresponding author
# (joint) last author

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