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Title: Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position
Authors: Topalis, Dimitrios ×
Alvarez, K
Barral, K
Munier-Lehmann, H
Schneider, B
Véron, M
Guerreiro, C
Mulard, L
El-Amri, C
Canard, B
Deville-Bonne, D #
Issue Date: Apr-2008
Publisher: Marcel Dekker
Series Title: Nucleosides, Nucleotides & Nucleic Acids vol:27 issue:4 pages:319-31
Abstract: Adenylate kinases are involved in the activation of antiviral drugs such as the acyclic phosphonates analogs PMEA and (R)PMPA. We examine the in vitro phosphorylation of PMEA and PMPA bearing a borano- or a H- group on the phosphorus atom. The alpha-borano or alpha-H on PMEA and PMPA were detrimental to the activity of recombinant human AMP kinases 1 and 2. Docking PMEA to the active site of AMP kinase 1 indicated that the borano group may prevent two conserved critical Arg interactions with the alpha-phosphate, resulting in substrate bad positioning.
URI: 
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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