Title: Serum concentrations of myostatin and myostatin-interacting proteins do not differ between young and sarcopenic elderly men
Authors: Ratkevicius, A ×
Joyson, A
Selmer, I
Dhanani, T
Grierson, C
Tommasi, A M
de Vries, Annick
Rauchhaus, P
Crowther, D
Alesci, S
Yaworsky, P
Gilbert, F
Redpath, T W
Brady, J
Fearon, K C H
Reid, D M
Greig, C A
Wackerhage, H #
Issue Date: Jun-2011
Publisher: Gerontological Society of America
Series Title: Journals of Gerontology A, Biological Sciences and Medical Sciences vol:66 issue:6 pages:620-626
Abstract: Sarcopenia is the loss of muscle size and function during ageing. The aim of this study was to test whether serum concentrations of myostatin and interacting proteins (GASP-1, FLRG, and follistatin) differed between young and elderly sarcopenic men. Isometric knee extensor maximal voluntary contraction and quadriceps cross-sectional area (magnetic resonance imaging measurement) were significantly higher in young (22 ± 2 years; 266 ± 54 N/m; 8,686 ± 1,154 mm(2)) than in mildly sarcopenic (69 ± 3 years; 183 ± 17 N/m; 6,621±718 mm(2)) and severely sarcopenic men (76 ± 6 years; 127 ± 23 N/m; 5,846 ± 591 mm(2)), respectively (p ≤ .01 for all comparisons). There was a trend (p = .06) toward higher FLRG in young (20 ± 8 ng/mL) than in mildly (15 ± 6 ng/mL) and severely sarcopenic men (17 ± 8 ng/mL). Myostatin, follistatin, GASP-1, tumor necrosis factor α, and interleukin-6 did not differ significantly. Insulin-like growth factor-1 and free testosterone were both significantly lower in sarcopenic men (p < .001). This suggests that altered serum concentrations of myostatin and myostatin-interacting proteins are not contributing to sarcopenia with the possible exception of FLRG.
ISSN: 1079-5006
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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