Title: ATP-citrate lyase: a key player in cancer metabolism
Authors: Zaidi, Nousheen ×
Swinnen, Johan
Smans, Karine #
Issue Date: Aug-2012
Publisher: Waverly Press
Series Title: Cancer Research vol:72 issue:15 pages:3709-3714
Abstract: ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes the generation of acetyl CoA from citrate. Acetyl CoA is a vital building block for the endogenous biosynthesis of fatty acids and cholesterol and is involved in isoprenoid-based protein modifications. Acetyl CoA is also required for acetylation reactions that modify proteins, such as histone acetylation. ACLY is upregulated or activated in several types of cancers, and its inhibition is known to induce proliferation arrest in cancer cells both in vitro and in vivo. The present review highlights current knowledge about the role of ACLY in cancer cells, with special reference to the different pathways that are linked by ACLY.
ISSN: 0008-5472
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Lipid Metabolism and Cancer (+)
× corresponding author
# (joint) last author

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