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Title: Tuning efficiency of the 4-exo-trig cyclization by the electronic effect: ring closure of 3,3-difluoro-4-pentenyl carbon radicals and synthesis of a gem-difluorocyclobutane nucleoside
Authors: Kumamoto, Hiroki ×
Kawahigashi, Sachiko
Wakabayashi, Hiromi
Nakano, Tomohiko
Miyaike, Tomoko
Kitagawa, Yasuyuki
Abe, Hiroshi
Ito, Mika
Haraguchi, Kazuhiro
Balzarini, Jan
Baba, Masanori
Tanaka, Hiromichi #
Issue Date: Oct-2012
Publisher: Royal Society of Chemistry
Series Title: Chemical Communications vol:48 issue:89 pages:10993-10995
Abstract: 4-exo-trig Cyclization reaction of a 4-pentenyl carbon radical containing the gem-difluoromethylene moiety adjacent to a radical accepting α,β-unsaturated ester was found to proceed efficiently to furnish a novel gem-difluorocyclobutane derivative. The cyclized product could be transformed into a gem-difluoromethylene analogue of oxetanocin T.
URI: 
ISSN: 1359-7345
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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