Title: Acyclic nucleoside phosphonates: a key class of antiviral drugs
Authors: De Clercq, Erik ×
Holý, Antonín #
Issue Date: Nov-2005
Series Title: Nature reviews. Drug discovery vol:4 issue:11 pages:928-40
Abstract: Almost 20 years after the broad antiviral activity spectrum of the first acyclic nucleoside phosphonates was described, several of these compounds have become important therapies for DNA virus and retrovirus infections. Here, we review the discovery and development of acyclic nucleoside phosphonates, focusing on cidofovir and its potential in the treatment of various herpes-, papilloma-, polyoma-, adeno- and pox-virus infections, adefovir for the treatment of hepatitis B and tenofovir for the treatment of AIDS and the prevention of HIV infections.
ISSN: 1474-1776
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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