Title: Synthetic and Structural Exploration of [2(4)]Tetrathiacalix[2]arene[2]pyrimidines
Authors: Sonawane, Mahendra Punjaji ×
Van Hecke, Kristof
Jacobs, Jeroen
Thomas, Joice
Van Meervelt, Luc
Dehaen, Wim
Van Rossom, Wim #
Issue Date: Oct-2012
Publisher: American Chemical Society
Series Title: Journal of Organic Chemistry vol:77 issue:19 pages:8444-8450
Article number: 10.1021/jo301321w
Abstract: A novel class of two atom bridged metacyclophanes-[2(4)]thiacalix[2]arene[2]pyrimidines-has been synthesized via a straightforward S(N)Ar reaction. The conformational properties and intra-annular dimensions of the [2(4)]thiacalix[2]arene[2]pyrimidines were evaluated by X-ray structure analysis and compared with known homothia- and thiacalixarenes. Post-macrocyclization oxidation of the bridging sulfur moieties resulted in a [2(4)]sulfonylcalix[2]arene[2]pyrimidine, which gave access to an unexplored cavity size among sulfonylcalixarenes.
ISSN: 0022-3263
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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