Molecular, cellular and physiological characterization of the cancer cachexia-inducing C26 colon carcinoma in mouse
Aulino, Paola × Berardi, Emanuele Cardillo, Veronica M Rizzuto, Emanuele Perniconi, Barbara Ramina, Carla Padula, Fabrizio Spugnini, Enrico P Baldi, Alfonso Faiola, Fabio Adamo, Sergio Coletti, Dario #
BMC Cancer vol:10 pages:363
The majority of cancer patients experience dramatic weight loss, due to cachexia and consisting of skeletal muscle and fat tissue wasting. Cachexia is a negative prognostic factor, interferes with therapy and worsens the patients' quality of life by affecting muscle function. Mice bearing ectopically-implanted C26 colon carcinoma are widely used as an experimental model of cancer cachexia. As part of the search for novel clinical and basic research applications for this experimental model, we characterized novel cellular and molecular features of C26-bearing mice.