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Title: Skeletal muscle is enriched in hematopoietic stem cells and not inflammatory cells in cachectic mice
Authors: Berardi, Emanuele ×
Aulino, Paola
Murfuni, Ivana
Toschi, Angelica
Padula, Fabrizio
Scicchitano, Bianca M
Coletti, Dario
Adamo, Sergio #
Issue Date: Mar-2008
Publisher: Butterworths
Series Title: Neurological Research vol:30 issue:2 pages:160-9
Abstract: Cachexia, a debilitating syndrome characterized by skeletal muscle wasting, is associated to many chronic diseases and diminishes the quality of life and survival of patients. Tumor-derived factors and proinflammatory cytokines, including TNF-alpha, IL-6 and IL-1 beta, mediate cachexia. In response to elevated cytokine levels, increased proteasome-mediated proteolysis and auto-phagocytosis result in muscle wasting. The histologic features of muscle cachexia are not fully elucidated. Therefore, we analysed alterations of different cell populations in cachectic muscle.
URI: 
ISSN: 0161-6412
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Embryo and Stemcells (-)
× corresponding author
# (joint) last author

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