Skeletal muscle is enriched in hematopoietic stem cells and not inflammatory cells in cachectic mice
Berardi, Emanuele × Aulino, Paola Murfuni, Ivana Toschi, Angelica Padula, Fabrizio Scicchitano, Bianca M Coletti, Dario Adamo, Sergio #
Neurological Research vol:30 issue:2 pages:160-9
Cachexia, a debilitating syndrome characterized by skeletal muscle wasting, is associated to many chronic diseases and diminishes the quality of life and survival of patients. Tumor-derived factors and proinflammatory cytokines, including TNF-alpha, IL-6 and IL-1 beta, mediate cachexia. In response to elevated cytokine levels, increased proteasome-mediated proteolysis and auto-phagocytosis result in muscle wasting. The histologic features of muscle cachexia are not fully elucidated. Therefore, we analysed alterations of different cell populations in cachectic muscle.