Title: Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles
Authors: Garuti, Laura ×
Roberti, Marinella
De Clercq, Erik #
Issue Date: Oct-2002
Series Title: Bioorganic & medicinal chemistry letters vol:12 issue:19 pages:2707-10
Abstract: Some benzimidazolyl sulphones were synthesized and evaluated for their antiviral and antiproliferative properties. Compound 10 displayed significant and selective activity against human cytomegalovirus (CMV), compound 14 showed activity against varicella zoster virus (VZV). The compounds were further evaluated for inhibitory effect on the proliferation of murine leukemia cells and human T-lymphocyte cells. Marked cytotoxicity was noted with different derivatives. Some structure-activity relationships are discussed.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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