Title: CXCR4 is the primary receptor for feline immunodeficiency virus in astrocytes
Authors: Nakagaki, K ×
Nakagaki, K
Takahashi, K
Schols, Dominique
De Clercq, Erik
Tabira, T #
Issue Date: Oct-2001
Series Title: Journal of neurovirology vol:7 issue:5 pages:487-92
Abstract: Feline astrocytes were productively infected with the Crandell feline kidney (CrFK) cell-adapted feline immunodeficiency virus (FIV) Petaluma strain in a primary culture. They expressed mRNA of CXCR4, and the FIV infection was blocked by stromal cell-derived factor 1alpha (SDF-1alpha), SDF-1beta, or the bicyclam AMD3100 in a dose-dependent manner. These observations suggest that, like FIV infection in CrFK cells and lymphocytes, the virus uses CXCR4 as a primary receptor for infecting astrocytes and this can be a possible natural model for AIDS dementia complex.
ISSN: 1355-0284
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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